The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II.

@article{Qiu2006TheSS,
  title={The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II.},
  author={Hongfang Qiu and Cuihua Hu and C Wong and Alan G Hinnebusch},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 8},
  pages={3135-48}
}
The Paf1 complex (Paf1C) interacts with RNA polymerase II (Pol II) and promotes histone methylation of transcribed coding sequences, but the mechanism of Paf1C recruitment is unknown. We show that Paf1C is not recruited directly by the activator Gcn4p but is dependent on preinitiation complex assembly and Ser5 carboxy-terminal domain phosphorylation for optimal association with ARG1 coding sequences. Importantly, Spt4p is required for Paf1C occupancy at ARG1 (and other genes) and for Paf1C… CONTINUE READING
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