The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1.

Abstract

The oncogene E2a-Pbx1 is formed by the t(1;19) translocation, which joins the N-terminal transactivation domain of E2a with the C-terminal homeodomain of PBX1. The goal of this work was to elucidate the mechanisms by which E2a-Pbx1 can lead to deregulated target gene expression. For reporter constructs it was shown that E2a-Pbx1 can activate transcription… (More)
DOI: 10.1080/10428190902836107

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Cite this paper

@article{Scheele2009TheSC, title={The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1.}, author={J{\"{u}rgen S. Scheele and Mateusz Kolanczyk and Melanie P. Gantert and Tomasz Zemojtel and Annette Dorn and David B Sykes and Dietrich C. C. Moebest and Mark P. Kamps and Daniel R{\"a}pple}, journal={Leukemia & lymphoma}, year={2009}, volume={50 5}, pages={816-28} }