The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter

@article{Cater2015TheSP,
  title={The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter},
  author={Rosemary J. Cater and Renae M Ryan and Robert J Vandenberg},
  journal={Neurochemical Research},
  year={2015},
  volume={41},
  pages={593-599}
}
Transporters and ion channels are conventionally categorised into distinct classes of membrane proteins. However, some membrane proteins have a split personality and can function as both transporters and ion channels. The excitatory amino acid transporters (EAATs) in particular, function as both glutamate transporters and chloride (Cl−) channels. The EAATs couple the transport of glutamate to the co-transport of three Na+ ions and one H+ ion into the cell, and the counter-transport of one K… CONTINUE READING
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