The Spir actin organizers are involved in vesicle transport processes

  title={The Spir actin organizers are involved in vesicle transport processes},
  author={Eugen Kerkhoff and Jeremy C Simpson and Cornelia B. Leberfinger and Ines M. Otto and Tobias Doerks and Peer Bork and Ulf R{\"u}diger Rapp and Thomas Raabe and Rainer Pepperkok},
  journal={Current Biology},
The p150-Spir protein, which was discovered as a phosphorylation target of the Jun N-terminal kinase, is an essential regulator of the polarization of the Drosophila oocyte. Spir proteins are highly conserved between species and belong to the family of Wiskott-Aldrich homology region 2 (WH2) proteins involved in actin organization. The C-terminal region of Spir encodes a zinc finger structure highly homologous to FYVE motifs. A region with high homology between the Spir family proteins is… CONTINUE READING
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