The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity

@inproceedings{Kempf2014TheSR,
  title={The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity},
  author={Anissa Kempf and Bjoern Tews and Michael E. Arzt and Oliver Weinmann and Franz Josef Obermair and Vincent Pernet and Marta Zagrebelsky and Andrea Delekate and Cristina Iobbi and Ajmal Zemmar and Zorica Ristic and Miriam Gullo and Peter Spies and Dana A. Dodd and Daniel Gygax and Martin Korte and Martin E. Schwab},
  booktitle={PLoS biology},
  year={2014}
}
Nogo-A is a membrane protein of the central nervous system (CNS) restricting neurite growth and synaptic plasticity via two extracellular domains: Nogo-66 and Nogo-A-Δ20. Receptors transducing Nogo-A-Δ20 signaling remained elusive so far. Here we identify the G protein-coupled receptor (GPCR) sphingosine 1-phosphate receptor 2 (S1PR2) as a Nogo-A-Δ20-specific receptor. Nogo-A-Δ20 binds S1PR2 on sites distinct from the pocket of the sphingolipid sphingosine 1-phosphate (S1P) and signals via the… CONTINUE READING
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