The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity

@inproceedings{Kempf2014TheSR,
  title={The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity},
  author={Anissa Kempf and Bj{\"o}rn Tews and Michael E. Arzt and Oliver Weinmann and Franz Josef Obermair and Vincent Pernet and Marta Zagrebelsky and Andrea Delekate and Cristina Iobbi and Ajmal Zemmar and Zorica Ristic and Miriam Gullo and Peter Spies and Dana A. Dodd and Daniel Gygax and Martin Korte and Martin E. Schwab},
  booktitle={PLoS biology},
  year={2014}
}
Nogo-A is a membrane protein of the central nervous system (CNS) restricting neurite growth and synaptic plasticity via two extracellular domains: Nogo-66 and Nogo-A-Δ20. Receptors transducing Nogo-A-Δ20 signaling remained elusive so far. Here we identify the G protein-coupled receptor (GPCR) sphingosine 1-phosphate receptor 2 (S1PR2) as a Nogo-A-Δ20-specific receptor. Nogo-A-Δ20 binds S1PR2 on sites distinct from the pocket of the sphingolipid sphingosine 1-phosphate (S1P) and signals via the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 51 CITATIONS, ESTIMATED 70% COVERAGE

RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas

  • Acta Neuropathologica
  • 2019
VIEW 8 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

New Insights into the Roles of Nogo-A in CNS Biology and Diseases

  • Neurochemical Research
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Tetraspanin-3 is an organizer of the multi-subunit Nogo-A signaling complex.

Nina K Thiede-Stan, Björn Tews, +3 authors Martin E. Schwab
  • Journal of cell science
  • 2015
VIEW 25 EXCERPTS
CITES BACKGROUND & METHODS

FILTER CITATIONS BY YEAR

2014
2019

CITATION STATISTICS

  • 7 Highly Influenced Citations

  • Averaged 9 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2003
VIEW 9 EXCERPTS

Sphingosine-1-phosphate: an enigmatic signalling lipid

  • Nature Reviews Molecular Cell Biology
  • 2003
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2013
VIEW 1 EXCERPT