The Spectrum of Allergens in Ragweed and Mugwort Pollen

@article{Wopfner2005TheSO,
  title={The Spectrum of Allergens in Ragweed and Mugwort Pollen},
  author={Nicole Wopfner and Gabriele Gadermaier and Matthias Egger and Riccardo Asero and Christof Ebner and Beatrice Jahn-Schmid and Fatima Ferreira},
  journal={International Archives of Allergy and Immunology},
  year={2005},
  volume={138},
  pages={337 - 346}
}
Ragweed and mugwort are important allergenic weeds belonging to the Asteraceae or Compositae plant family. Pollen of mugwort is one of the main causes of allergic reactions in late summer and autumn in Europe and affects about 10–14% of the patients suffering from pollinosis. Ragweed pollen represents the major source of allergenic protein in the United States, with a prevalence of about 50% in atopic individuals. In Europe, ragweed allergy is now rapidly increasing particularly in certain… 

Figures and Tables from this paper

A New Allergen from Ragweed (Ambrosia artemisiifolia) with Homology to Art v 1 from Mugwort*

TLDR
Immunological characterization revealed that the recombinant ragweed protein reacted with >30% of the weed pollen allergic patients, therefore, this protein from ragweed pollen constitutes a novel important ragweed allergen and has been designated Amb a 4.

Allergen, and Its Mugwort Homolog Art v 6 between Amb a 1, the Major Ragweed Pollen Humoral and Cellular Cross-Reactivity

TLDR
Amb a 1 can elicit more diverse allergen-specific IgE and T cell responses than Art v 6 and dominates the cross-reactivity with its homolog, which may facilitate sensitization to Amb a 1 by epitope cross-recognition of T and B cells.

Cross-allergenicity of pollens from the Compositae family: Artemisia vulgaris, Dendranthema grandiflorum, and Taraxacum officinale.

Pectate Lyase Pollen Allergens: Sensitization Profiles and Cross-Reactivity Pattern

TLDR
The sensitization pattern of different cohorts correlated with pollen exposure, which should be considered for future allergy diagnosis and therapy, and pectate lyase pollen allergens in four categories, at which each category has the potential to sensitize predisposed individuals.

Immunoproteomic characterization of Ambrosia artemisiifolia pollen allergens in canine atopic dermatitis.

Walls of allergenic pollen: Special reference to the endexine

TLDR
The question is raised whether pollen morphology and ultrastructure might contribute to the accessibility and therefore allergenicity of allergenic proteins.

Similar Allergenicity to Different Artemisia Species Is a Consequence of Highly Cross-Reactive Art v 1-Like Molecules

TLDR
It is demonstrated that DPLPs in various Artemisia species have high allergenic potential, and related Artemisiaspecies need to be considered to be allergen elicitors, especially due to the consideration of potential geographic expansion due to climatic changes.
...

References

SHOWING 1-10 OF 75 REFERENCES

Identification of common allergenic structures in mugwort and ragweed pollen.

Molecular and Immunological Characterization of Profilin from Mugwort Pollen

TLDR
The isolation and characterization of mugwort pollen cDNA clones coding for two isoforms of the panallergen profilin indicated that the protein exists in solution as dimers and tetramers stabilized by sulfydryl and/or ionic interactions, not an artifact resulting from the recombinant production of the allergen.

Biology of weed pollen allergens

TLDR
Weeds represent a heterogeneous group of plants, usually defined by no commercial or aesthetic value, and contain the panallergens profilin and calcium-binding proteins, which are responsible for extensive cross-reactivity among pollensensitized patients.

Two Novel Types of O-Glycans on the Mugwort Pollen Allergen Art v 1 and Their Role in Antibody Binding*

TLDR
Although the authors could not observe antibody binding by the polysaccharide, the single hydroxyproline-linked β-arabinose residues appeared to react with the antibodies and constitute a new, potentially cross-reactive, carbohydrate determinant in plant proteins.

Analysis of cross-reactivity between sunflower pollen and other pollens of the Compositae family.

Antigenic relationship between mugwort and ragweed pollens by crossed immunoelectrophoresis.

TLDR
There is no cross-antigenicity between mugwort and ragweed pollens, as developed and observed by immunization on New Zealand white rabbits and crossed immunoelectrophoresis with two pollen extracts.

Identification of cross-reactive and genuine Parietaria judaica pollen allergens.

BACKGROUND The weed Parietaria judaica is one of the most important pollen allergen sources in the Mediterranean area. OBJECTIVE We sought to identify P judaica pollen allergen, which might be used

An epidemiological survey on the allergological importance of some emerging pollens in Italy.

TLDR
In the great majority of patients, positivity for these pollens was associated with positivity to the better recognized group of pollen allergens, although in some cases they were the primary pathogenic agent.

Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin‐like and a hydroxyproline‐rich domain

TLDR
Re recombinant nonglycosylated Art v 1 is a good starting template for engineering hypoallergenic vaccines for weed‐pollen therapy and the involvement of the defensin fold and posttranslational modifications in the formation of epitopes recognized by IgE antibodies from allergic patients was revealed.
...