The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

@article{GuryBenAri2016TheSA,
  title={The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome},
  author={Meital Gury-BenAri and Christoph A. Thaiss and Nicolas Serafini and Deborah R. Winter and Amir Giladi and David Lara-Astiaso and Maayan Levy and Tomer Meir Salame and Assaf Weiner and Eyal David and Hagit Shapiro and Mally Dori-Bachash and Meirav Pevsner-Fischer and Erika Lorenzo-Vivas and Hadas Keren-Shaul and Franziska Paul and Alon Harmelin and G{\'e}rard Eberl and Shalev Itzkovitz and Amos Tanay and James P Di Santo and Eran Elinav and Ido Amit},
  journal={Cell},
  year={2016},
  volume={166},
  pages={1231-1246.e13}
}
Innate lymphoid cells (ILCs) are critical modulators of mucosal immunity, inflammation, and tissue homeostasis, but their full spectrum of cellular states and regulatory landscapes remains elusive. Here, we combine genome-wide RNA-seq, ChIP-seq, and ATAC-seq to compare the transcriptional and epigenetic identity of small intestinal ILCs, identifying… CONTINUE READING