The Specificity of the FOXL2 c.402C>G Somatic Mutation: A Survey of Solid Tumors

  title={The Specificity of the FOXL2 c.402C>G Somatic Mutation: A Survey of Solid Tumors},
  author={Kasmintan Schrader and Bella Gorbatcheva and Janine Senz and Alireza Heravi-Moussavi and Nataliya Melnyk and C. Jorge E. Salamanca and Sarah L. Maines-Bandiera and Susanna L. Cooke and Peter Leung and James D. Brenton and Cyril Blake Gilks and J. Monahan and David G. Huntsman},
  booktitle={PloS one},
BACKGROUND A somatic mutation in the FOXL2 gene is reported to be present in almost all (97%; 86/89) morphologically defined, adult-type, granulosa-cell tumors (A-GCTs). This FOXL2 c.402C>G mutation changes a highly conserved cysteine residue to a tryptophan (p.C134W). It was also found in a minority of other ovarian malignant stromal tumors, but not in benign ovarian stromal tumors or unrelated ovarian tumors or breast cancers. METHODOLOGY/PRINCIPAL FINDINGS Herein we studied other cancers… CONTINUE READING


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