The Specificity of Serological Reactions

@article{Landsteiner1936TheSO,
  title={The Specificity of Serological Reactions},
  author={Karl Landsteiner},
  journal={The Indian Medical Gazette},
  year={1936},
  volume={71},
  pages={430 - 430}
}
This little book brings within the reach of workers in immunology almost a fabulous wealth of references in an exceptionally small compass. The references are indicated, generally, serially by small numerals, expanded in footnotes and given at length at the end of each section. By this plan the narrative has been made continuous and concise. For 146 pages of subject-matter there are no less than 1,197 references. After a short introduction to ' elementary concepts and phenomena of serology' for… 
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1,007 Citations
Highly Influential Citations
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Background Citations
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1,007 Citations

Immunologic specificity: solutions
The specificity of immunological reactions.
Chapter 9 Antibody specificity and diversity: The proteins (Part I)
Development of the concept of immunologic specificity: IV.
Antibodies to enzymes--a tool in the study of antigenic specificity determinants.
  • R. Arnon
  • Biology
    Current topics in microbiology and immunology
  • 1971
TLDR
The study of antigenic specificity determinants has long been a subject of interest and the extensive studies on cytochrome c have indeed demonstrated the power of this analytical approach.
Comparative serology of some branchyuran Crustacea and studies in hemocyanin correspondence.
TLDR
Antigens tested for comparability under a variety of the circumstances met in ordinary laboratory handling such as freezing, filtration and centrifugation, showed no significant deviation from each other in their serological activity.
Antigen Recognition: 100 Years After Landsteiner
TLDR
Today, having the benefit of over 60 years of further intensive study in many laboratories the authors can define specificity simply and more clearly as the ability “…to bind one unique chemical structure more strongly than a number of similar alternatives”.
A conception of immunological specificity
TLDR
Investigations which have contributed to the present-day conception of this aspect of immunity reactions are not discussed in detail.
Some Current Concepts of the Chemical Nature of Antigens and Antibodies
TLDR
It is somewhat paradoxical that at present these studies have contributed as much if not more to the understanding of the physical nature of proteins than to an understanding of immunity mechanisms.
Production of hypersensitivity to skin in animals.
TLDR
This new concept that an organism can develop widespread or localized tissue disease because it has turned on itself with the weapon of hypersensitivity owes its existence to fundamental work begun early in the century during which 2 important observations were made.
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