The South Amerindian allotype HLA-B*3909 has the largest known similarity in peptide specificity and common natural ligands with HLA-B27.

@article{Yage1999TheSA,
  title={The South Amerindian allotype HLA-B*3909 has the largest known similarity in peptide specificity and common natural ligands with HLA-B27.},
  author={Jes{\'u}s Yag{\"u}e and Manuel Jos{\'e} Moreno Ramos and Jes{\'u}s Gonz{\'a}lez – V{\'a}zquez and Anabel Marina and Juan P. Albar and Jos{\'e} A L{\'o}pez de Castro},
  journal={Tissue antigens},
  year={1999},
  volume={53 3},
  pages={227-36}
}
HLA-B*3909 has only been found among South Amerindians, and presumably arose locally in these populations. It differs from B*3901 by a single Tyr to Ser change at position 99. To analyze the influence of this polymorphism on peptide specificity, pool sequence analysis and sequencing of multiple individual ligands from B*3901 and B*3909 were carried out. Both allotypes bind peptides with Arg2 or His2 and nonpolar C-terminal residues. However, whereas His2 is the predominant B*3901 motif, a… CONTINUE READING