The SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice

@inproceedings{KruegerBurg2016TheSA,
  title={The SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice},
  author={Dilja Krueger-Burg and Daniela Winkler and Mi{\vs}o Mitkovski and Fernanda Pazotti Daher and Anja Ronnenberg and Oliver M Schl{\"u}ter and Ekrem Dere and Hannelore Ehrenreich},
  booktitle={Front. Behav. Neurosci.},
  year={2016}
}
Impairments in social skills are central to mental disease, and developing tools for their assessment in mouse models is essential. Here we present the SocioBox, a new behavioral paradigm to measure social recognition. Using this paradigm, we show that male wildtype mice of different strains can readily identify an unfamiliar mouse among 5 newly acquainted animals. In contrast, female mice exhibit lower locomotor activity during social exploration in the SocioBox compared to males and do not… CONTINUE READING
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