The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1

@article{Lnrt2007TheSI,
  title={The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1},
  author={P{\'e}ter L{\'e}n{\'a}rt and Mark Petronczki and Martin Steegmaier and Barbara Di Fiore and Jesse J. Lipp and Matthias Hoffmann and Wolfgang J. Rettig and Norbert Kraut and J. G. Peters},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={304-315}
}
BACKGROUND The mitotic kinases, Cdk1, Aurora A/B, and Polo-like kinase 1 (Plk1) have been characterized extensively to further understanding of mitotic mechanisms and as potential targets for cancer therapy. Cdk1 and Aurora kinase studies have been facilitated by small-molecule inhibitors, but few if any potent Plk1 inhibitors have been identified. RESULTS We describe the cellular effects of a novel compound, BI 2536, a potent and selective inhibitor of Plk1. The fact that BI 2536 blocks Plk1… CONTINUE READING
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