The Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Induces Apoptosis in Medulloblastoma and Glioblastoma Cells

@inproceedings{Ball2011TheSM,
  title={The Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Induces Apoptosis in Medulloblastoma and Glioblastoma Cells},
  author={Sarah Ball and Chenglong Li and Pui-kai Li and Jiayuh Lin},
  booktitle={PloS one},
  year={2011}
}
Tumors of the central nervous system represent a major source of cancer-related deaths, with medulloblastoma and glioblastoma being the most common malignant brain tumors in children and adults respectively. While significant advances in treatment have been made, with the 5-year survival rate for medulloblastoma at 70-80%, treating patients under 3 years of age still poses a problem due to the deleterious effects of radiation on the developing brain, and the median survival for patients with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

STAT inhibitors for cancer therapy

Journal of hematology & oncology • 2013
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Proceedings of the National Academy of Sciences of the United States of America • 2007
View 3 Excerpts
Highly Influenced

Design, synthesis, and studies of small molecule STAT3 inhibitors.

Bioorganic & medicinal chemistry letters • 2008
View 2 Excerpts

Malignant gliomas in adults.

The New England journal of medicine • 2008
View 3 Excerpts

Similar Papers

Loading similar papers…