The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.

@article{Jang2018TheSI,
  title={The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.},
  author={Cholsoon Jang and Sheng Hui and Wenyun Lu and Alexis J Cowan and Raphael J. Morscher and Gina Lee and Wei Liu and Gregory J Tesz and Morris J Birnbaum and Joshua D. Rabinowitz},
  journal={Cell metabolism},
  year={2018},
  volume={27 2},
  pages={
          351-361.e3
        }
}
Excessive consumption of sweets is a risk factor for metabolic syndrome. A major chemical feature of sweets is fructose. Despite strong ties between fructose and disease, the metabolic fate of fructose in mammals remains incompletely understood. Here we use isotope tracing and mass spectrometry to track the fate of glucose and fructose carbons in vivo, finding that dietary fructose is cleared by the small intestine. Clearance requires the fructose-phosphorylating enzyme ketohexokinase. Low… CONTINUE READING
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