The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.

Abstract

Transforming growth factor-beta (TGF-beta) family members signal through a unique set of intracellular proteins called Smads. Smad4, previously identified as the tumor suppressor DPC4, is functionally distinct among the Smad family, and is required for the assembly and transcriptional activation of diverse, Smad-DNA complexes. We previously identified a 48… (More)

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Cite this paper

@article{Caestecker2000TheSA, title={The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.}, author={Mark P. de Caestecker and Tetsutaro Yahata and D Wang and W Tony Parks and S. Huang and Caterina Hill and Toshi Shioda and Ann Roberts and Robert J. Lechleider}, journal={The Journal of biological chemistry}, year={2000}, volume={275 3}, pages={2115-22} }