The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

@article{Lee2011TheSH,
  title={The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo},
  author={Zheng Wei Lee and J. Zhou and C. Chen and Y. Zhao and C. Tan and L. Li and P. Moore and Lih-Wen Deng},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
  • Zheng Wei Lee, J. Zhou, +5 authors Lih-Wen Deng
  • Published 2011
  • Medicine, Chemistry
  • PLoS ONE
  • The slow-releasing hydrogen sulfide (H2S) donor, GYY4137, caused concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38) as determined by trypan blue exclusion. Sodium hydrosulfide (NaHS) was less potent and not active in all cell lines. A structural analogue of GYY4137 (ZYJ1122) lacking sulfur and thence not able to release H2S was inactive… CONTINUE READING
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    • 251
    • Highly Influenced
    • PDF
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    • 207
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    • 175
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 18 REFERENCES
    Clonogenic assay of cells in vitro
    • 2,304
    • PDF
    Hydrogen sulfide and cell signaling.
    • 884
    • PDF
    Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide
    • 520
    Hydrogen Sulfide Inhibits Rotenone-Induced Apoptosis via Preservation of Mitochondrial Function
    • 196
    • PDF
    Hydrogen sulfide induces human colon cancer cell proliferation: Role of Akt, ERK and p21
    • 116