The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

@article{Lin1999TheSD,
  title={The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene},
  author={L. Lin and J. Faraco and Robin Li and H. Kadotani and W. Rogers and Xiaoyan Lin and X. Qiu and P. J. D. Jong and S. Nishino and E. Mignot},
  journal={Cell},
  year={1999},
  volume={98},
  pages={365-376}
}
Narcolepsy is a disabling sleep disorder affecting humans and animals. It is characterized by daytime sleepiness, cataplexy, and striking transitions from wakefulness into rapid eye movement (REM) sleep. In this study, we used positional cloning to identify an autosomal recessive mutation responsible for this sleep disorder in a well-established canine model. We have determined that canine narcolepsy is caused by disruption of the hypocretin (orexin) receptor 2 gene (Hcrtr2). This result… Expand
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