The Ski protein family is required for MeCP2-mediated transcriptional repression.

@article{Kokura2001TheSP,
  title={The Ski protein family is required for MeCP2-mediated transcriptional repression.},
  author={Kenji Kokura and Sunil C. Kaul and Renu Wadhwa and Teruaki Nomura and Md Matiullah Khan and Toshie Shinagawa and Takashi Yasukawa and Clemencia Colmenares and Shunsuke Ishii},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 36},
  pages={34115-21}
}
DNA methylation is essential for development in the mouse and plays an important role in inactivation of the X chromosome and genomic imprinting. MeCP2 is the founder member of a family of methyl-CpG-binding proteins. MeCP2 directly binds to the co-repressor mSin3, which interacts with class I histone deacetylase, recruiting them to methyl-CpG regions to suppress transcription. Here, we report that MeCP2 directly binds to two co-repressors, c-Ski and N-CoR, in addition to mSin3A, and that the c… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 85 extracted citations

MeCP2 in central nervous system glial cells: current updates.

Acta neurobiologiae experimentalis • 2018
View 4 Excerpts
Highly Influenced

The epigenetics of sex differences in the brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 6 Excerpts
Highly Influenced

The role of MeCP2 in the brain.

Annual review of cell and developmental biology • 2011
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…