The Ski protein family is required for MeCP2-mediated transcriptional repression.

  title={The Ski protein family is required for MeCP2-mediated transcriptional repression.},
  author={Kenji Kokura and Sunil C. Kaul and Renu Wadhwa and Teruaki Nomura and Md Matiullah Khan and Toshie Shinagawa and Takashi Yasukawa and Clemencia Colmenares and Shunsuke Ishii},
  journal={The Journal of biological chemistry},
  volume={276 36},
DNA methylation is essential for development in the mouse and plays an important role in inactivation of the X chromosome and genomic imprinting. MeCP2 is the founder member of a family of methyl-CpG-binding proteins. MeCP2 directly binds to the co-repressor mSin3, which interacts with class I histone deacetylase, recruiting them to methyl-CpG regions to suppress transcription. Here, we report that MeCP2 directly binds to two co-repressors, c-Ski and N-CoR, in addition to mSin3A, and that the c… CONTINUE READING


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