The Sirtuin family: therapeutic targets to treat diseases of aging.

  title={The Sirtuin family: therapeutic targets to treat diseases of aging.},
  author={Jill C. Milne and John M Denu},
  journal={Current opinion in chemical biology},
  volume={12 1},
Sirtuins have emerged as therapeutic targets to treat age-related diseases. There are seven human Sirtuins (SIRT1-7) that display diversity in cellular localization and function. Growing evidence suggests that small-molecule activators of SIRT1 may counteract age-related afflictions such as type 2 diabetes. Alternatively, inhibitors of SIRT2 may be useful in the treatment of neurodegenerative diseases such as Parkinson's disease. Recent discoveries of small-molecule and protein modulators of… CONTINUE READING
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