The Sir2-Sum1 Complex Represses Transcription Using Both Promoter-Specific and Long-Range Mechanisms to Regulate Cell Identity and Sexual Cycle in the Yeast Kluyveromyces lactis

@inproceedings{Hickman2009TheSC,
  title={The Sir2-Sum1 Complex Represses Transcription Using Both Promoter-Specific and Long-Range Mechanisms to Regulate Cell Identity and Sexual Cycle in the Yeast Kluyveromyces lactis},
  author={Meleah A Hickman and Laura N. Rusch{\'e}},
  booktitle={PLoS genetics},
  year={2009}
}
Deacetylases of the Sir2 family regulate lifespan and response to stress. We have examined the evolutionary history of Sir2 and Hst1, which arose by gene duplication in budding yeast and which participate in distinct mechanisms of gene repression. In Saccharomyces cerevisiae, Sir2 interacts with the SIR complex to generate long-range silenced chromatin at the cryptic mating-type loci, HMLalpha and HMRa. Hst1 interacts with the SUM1 complex to repress sporulation genes through a promoter… CONTINUE READING

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An Evolutionary Perspective on Yeast Mating-Type Switching

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Transcriptional silencing functions of the yeast protein Orc1/Sir3 subfunctionalized after gene duplication.

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Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES