The Significance of Pneumococcal Types

  title={The Significance of Pneumococcal Types},
  author={Fred. Griffith},
  journal={Journal of Hygiene},
  pages={113 - 159}
  • F. Griffith
  • Published 1 January 1928
  • Biology
  • Journal of Hygiene
1. In the course of the examination of sputum from cases of lobar pneumonia, observations have been made on the incidence of the chief types of pneumococci. In the district from which the material was obtained, there was an apparent local diminution in the number of cases of lobar pneumonia due to Type II the figures were 326 per cent. of Type II cases in the period 1920–22, and only 74 per cent. in the period 1924–27. The incidence of Type I was approximately the same in the two periods, the… 
The Serological Classification of Streptococcus pyogenes
  • F. Griffith
  • Medicine, Biology
    Epidemiology and Infection
  • 1934
The haemolytic streptococci associated with scarlet fever, tonsillitis, septic conditions, etc., belong to one group or species designated Streptococcus pyogenes, and the principles involved in the serological classification of a bacterial group are discussed.
The History of Pneumococcal Disease
This chapter reviews some of the major events in the history of Streptococcus pneumoniae—events that have led to our modern understanding of the pathogenesis, diagnosis, treatment, and prevention of
The Relation of Virulence in Pneumococci to Disease, with a Comparison of Virulence of the Different Types of Pneumococci in various Pathological Conditions
  • C. Whittle
  • Medicine, Biology
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  • 1928
Pneumococci form a group of organisms of which the individual strains exhibit wide differences in character. Like the streptococci, certain types of which they closely resemble, they show a
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  • S. Palchaudhuri
  • Medicine, Biology
    Journal of Biotechnology & Bioinformatics Research
  • 2022
This work has extensively studied lysogeny with E.coli K-12 and its virus bacteriophage lambda and found that the virus COVID-19 (RNA genome) in the authors' respiratory cells may be responsible for their antigenic variation.
The discovery of pneumococcal type transformation: an appreciation
  • W. Hayes
  • Biology, Medicine
    Journal of Hygiene
  • 1966
A series of careful and painstaking experiments show beyond doubt that the ability to produce a polysaccharide capsule can regularly be restored to ‘rough’ (R) strains of pneumococci which have lost it, by the subcutaneous inoculation of mice with an excess of heat-killed, capsulated (S) virulent bacteria.
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Solution for the global population is to develop now an alternative preventive, lowcost hometherapy by inhibiting the growth of this pathogen by understanding the growth curve of such a pathogen.
Changing the Ecology of Pneumococci with Antibiotics and Vaccines
This chapter describes the mechanisms and consequences for the pneumococcal population of the selective pressures imposed by antibiotics and vaccines, and emphasizes the effects of vaccines and antibiotics on the ecology of pneumococci taking place against a background of a genetically diverse population structured by direct and indirect ecological interactions between strains.