The Significance of PITX2 Overexpression in Human Colorectal Cancer

  title={The Significance of PITX2 Overexpression in Human Colorectal Cancer},
  author={H. Hirose and H. Ishii and K. Mimori and F. Tanaka and I. Takemasa and T. Mizushima and M. Ikeda and H. Yamamoto and M. Sekimoto and Y. Doki and M. Mori},
  journal={Annals of Surgical Oncology},
  • H. Hirose, H. Ishii, +8 authors M. Mori
  • Published 2011
  • Biology, Medicine
  • Annals of Surgical Oncology
  • PurposeThe paired-like homeodomain transcription factor 2 (PITX2) gene encodes a transcription factor controlled by the WNT/Dvl/CTNNB1 and Hedgehog/TGFB pathways in the pathogenesis of colorectal cancer (CRC). Although PITX2 is reportedly involved in various functions, including tissue development by controlling cell growth, its significance in CRC remains unclear. We report our findings regarding abnormal PITX2 expression in human CRC.MethodsPITX2 expression was evaluated in 5 human CRC cell… CONTINUE READING
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