The Significance of PITX2 Overexpression in Human Colorectal Cancer

@article{Hirose2011TheSO,
  title={The Significance of PITX2 Overexpression in Human Colorectal Cancer},
  author={H. Hirose and H. Ishii and K. Mimori and F. Tanaka and I. Takemasa and T. Mizushima and M. Ikeda and H. Yamamoto and M. Sekimoto and Y. Doki and M. Mori},
  journal={Annals of Surgical Oncology},
  year={2011},
  volume={18},
  pages={3005-3012}
}
  • H. Hirose, H. Ishii, +8 authors M. Mori
  • Published 2011
  • Biology, Medicine
  • Annals of Surgical Oncology
  • PurposeThe paired-like homeodomain transcription factor 2 (PITX2) gene encodes a transcription factor controlled by the WNT/Dvl/CTNNB1 and Hedgehog/TGFB pathways in the pathogenesis of colorectal cancer (CRC). Although PITX2 is reportedly involved in various functions, including tissue development by controlling cell growth, its significance in CRC remains unclear. We report our findings regarding abnormal PITX2 expression in human CRC.MethodsPITX2 expression was evaluated in 5 human CRC cell… CONTINUE READING
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    References

    SHOWING 1-10 OF 39 REFERENCES
    RGS16 Is a Marker for Prognosis in Colorectal Cancer
    • 24
    Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer.
    • 66
    Multiple roles of the candidate oncogene ZNF217 in ovarian epithelial neoplastic progression
    • 44
    • PDF
    Target genes of the WNT/beta-catenin pathway in Wilms tumors.
    • 49
    Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway
    • 147
    • Highly Influential
    • PDF
    Identification of a Wnt/Dvl/β-Catenin → Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development
    • 523
    • Highly Influential
    Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene.
    • 107
    • PDF
    Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma.
    • 104
    • PDF