The Significance of Interferon-γ–Triggered Internalization of Tight-Junction Proteins in Inflammatory Bowel Disease

@article{Chiba2006TheSO,
  title={The Significance of Interferon-$\gamma$–Triggered Internalization of Tight-Junction Proteins in Inflammatory Bowel Disease},
  author={Hideki Chiba and Takashi Kojima and Makoto Osanai and Norimasa Sawada},
  journal={Science's STKE},
  year={2006},
  volume={2006},
  pages={pe1 - pe1}
}
Disruption of the epithelial barrier function of tight junctions by the proinflammatory cytokine interferon (IFN)–γ plays a fundamental role in the pathogenesis of inflammatory bowel disease and other gastrointestinal disorders, but its precise mechanism has not been established. This Perspective provides an overview of how IFN-γ triggers barrier dysfunction and bacterial translocation in intestinal epithelial cells, and highlights the roles of internalization of tight-junction transmembrane… 

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It is suggested that IFN-γ affects barrier function in T84 cells by decreasing the levels of ZO-1 and perturbing apical actin organization, which leads to a disorganization of the tight junction and an increase in paracellular permeability.