The Signal Sequence Coding Region Promotes Nuclear Export of mRNA

@article{Palazzo2007TheSS,
  title={The Signal Sequence Coding Region Promotes Nuclear Export of mRNA},
  author={Alexander F Palazzo and Michael Springer and Y Shibata and Chung-Sheng Lee and Anusha P. Dias and Tom A. Rapoport},
  journal={PLoS Biology},
  year={2007},
  volume={5}
}
In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping. We have studied in mammalian cells the nuclear export of mRNAs that code for secretory proteins, which are targeted to the endoplasmic reticulum membrane by hydrophobic signal sequences. The mRNAs were injected into the nucleus or synthesized from injected or transfected DNA, and their export was followed by fluorescent in situ… Expand
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