The Sigma Class Glutathione Transferase from the Liver Fluke Fasciola hepatica

  title={The Sigma Class Glutathione Transferase from the Liver Fluke Fasciola hepatica},
  author={E James Lacourse and Samirah Perally and Russell M. Morphew and Joseph Vaughan Moxon and Mark Prescott and David J. Dowling and Sandra M O'neill and Anja Kipar and Udo Hetzel and Elizabeth M. Hoey and Rafael G{\'o}mez Zafra and Leandro Buffoni and Jos{\'e} P{\'e}rez Ar{\'e}valo and Peter M. Brophy},
  booktitle={PLoS neglected tropical diseases},
BACKGROUND Liver fluke infection of livestock causes economic losses of over US$ 3 billion worldwide per annum. The disease is increasing in livestock worldwide and is a re-emerging human disease. There are currently no commercial vaccines, and only one drug with significant efficacy against adult worms and juveniles. A liver fluke vaccine is deemed essential as short-lived chemotherapy, which is prone to resistance, is an unsustainable option in both developed and developing countries. Protein… CONTINUE READING
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A study of the liver of goats immunized with a synthetic peptide of the Sm14 antigen and challenged with Fasciola hepatica

  • R Zafra, L Buffoni, A Martı́nez-Moreno, A Pérez-Ecija, FJ Martinez-Moreno
  • Journal of Comparative Pathology
  • 2008
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