The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42

@inproceedings{Tien2016TheSE,
  title={The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42},
  author={Sui-Chih Tien and H Lee and Ya-Chi Yang and Miao-Hsia Lin and Yu-Ju Chen and Z F Chang},
  booktitle={Nature communications},
  year={2016}
}
Regulation of Shp2, a tyrosine phosphatase, critically influences the development of various diseases. Its role in epithelial lumenogenesis is not clear. Here we show that oncogenic Shp2 dephosphorylates Tuba to decrease Cdc42 activation, leading to the abnormal multi-lumen formation of epithelial cells. HDAC6 suppression reverses oncogenic Shp2-induced… CONTINUE READING