The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

Abstract

Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trigger cellular responses to telomere dysfunction, we crossed mTR-/- G6 mice that have short telomeres with mice heterozygous for telomerase (mTR+/-) that have long telomeres. The phenotype of the telomerase null offspring was similar to that of the late… (More)
DOI: 10.1016/S0092-8674(01)00504-9

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