The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

@article{Hemann2001TheST,
  title={The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability},
  author={M. Hemann and M. Strong and Ling-Yang Hao and C. Greider},
  journal={Cell},
  year={2001},
  volume={107},
  pages={67-77}
}
Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trigger cellular responses to telomere dysfunction, we crossed mTR-/- G6 mice that have short telomeres with mice heterozygous for telomerase (mTR+/-) that have long telomeres. The phenotype of the telomerase null offspring was similar to that of the late generation parent, although only half of the chromosomes were short. Strikingly, spectral karyotyping (SKY) analysis revealed that loss of… Expand
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References

SHOWING 1-10 OF 65 REFERENCES
Telomere length regulation.
  • C. Greider
  • Biology, Medicine
  • Annual review of biochemistry
  • 1996
Subsenescent Telomere Lengths in Fibroblasts Immortalized by Limiting Amounts of Telomerase*
Accumulation of short telomeres in human fibroblasts prior to replicative senescence.
Repair of telomeric DNA prior to replicative senescence
  • P. Lansdorp
  • Biology, Medicine
  • Mechanisms of Ageing and Development
  • 2000
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening.
Replicative Senescence and Cell Immortality: The Role of Telomeres and Telomerase
  • C. Chiu, C. Harley
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1997
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
...
1
2
3
4
5
...