The Shortest Isoform of Dystrophin (Dp40) Interacts with a Group of Presynaptic Proteins to Form a Presumptive Novel Complex in the Mouse Brain

@inproceedings{Tozawa2012TheSI,
  title={The Shortest Isoform of Dystrophin (Dp40) Interacts with a Group of Presynaptic Proteins to Form a Presumptive Novel Complex in the Mouse Brain},
  author={Takenori Tozawa and Kyoko Itoh and Takeshi Yaoi and So Tando and Masafumi Umekage and Hongmei Dai and Hajime Hosoi and Shinji Fushiki},
  booktitle={Molecular Neurobiology},
  year={2012}
}
Duchenne muscular dystrophy (DMD) causes cognitive impairment in one third of the patients, although the underlying mechanisms remain to be elucidated. Recent studies showed that mutations in the distal part of the dystrophin gene correlate well with the cognitive impairment in DMD patients, which is attributed to Dp71. The study on the expression of the shortest isoform, Dp40, has not been possible due to the lack of an isoform specific antibody. Dp40 has the same promoter as that found in… CONTINUE READING