The Shiga toxin genotype rather than the amount of Shiga toxin or the cytotoxicity of Shiga toxin in vitro correlates with the appearance of the hemolytic uremic syndrome.

@article{Orth2007TheST,
  title={The Shiga toxin genotype rather than the amount of Shiga toxin or the cytotoxicity of Shiga toxin in vitro correlates with the appearance of the hemolytic uremic syndrome.},
  author={Dorothea Orth and Katharina Grif and Abdul Basit Khan and Asma Naim and Manfred Paul Dierich and Reinhard Wuerzner},
  journal={Diagnostic microbiology and infectious disease},
  year={2007},
  volume={59 3},
  pages={235-42}
}
Shiga toxins (Stx) are believed to play a key role in the pathogenesis of diseases caused by Stx-producing Escherichia coli (STEC), including the potentially life-threatening hemolytic uremic syndrome (HUS). In this study, 201 STEC strains collected from patients and environmental sources were investigated with regard to the stx genotypes and pathogenicity. The stx(2) and stx(2c) alleles were associated with high virulence and the ability to cause HUS, whereas stx(2d), stx(2e,)stx(1), and stx… CONTINUE READING

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