The Shh signalling pathway in early tooth development.

  title={The Shh signalling pathway in early tooth development.},
  author={Zo{\"e} Hardcastle and Chi Chung Hui and Paul T Sharpe},
  journal={Cellular and molecular biology},
  volume={45 5},
The Sonic Hedgehog (Shh) signalling pathway has been proposed to play an important role in mammalian tooth development. We describe the spatial and temporal expression of genes in this pathway during early tooth development and interpret these patterns in terms of the likely roles of Shh signalling. We show that the two putative receptors of the Shh ligand, Ptc and Ptch-2, localise in different cells, suggesting Shh may function in different ways as an epithelial and mesenchymal signal. Shh… CONTINUE READING


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