The Serum Immunoglobulin G Glycosylation Signature of Gastric Cancer.

  title={The Serum Immunoglobulin G Glycosylation Signature of Gastric Cancer.},
  author={L. Renee Ruhaak and Donald A. Barkauskas and Javier M. Velandia Torres and Cara L. Cooke and Lauren D Wu and Carol D Stroble and Sureyya Ozcan and Cynthia Clark Williams and Margarita Camorlinga and David M. Rocke and Carlito B. Lebrilla and Jay V. Solnick},
  journal={EuPA open proteomics},
Biomarkers may facilitate detection of gastric cancer at an earlier stage and reduce mortality. Here we sought to determine if the glycosylation profile of serum immunoglobulin G (IgG) could distinguish patients with non-atrophic gastritis (NAG), duodenal ulcer (DU) and gastric cancer (GC). Serum IgG was released and analyzed using nano-LC-TOF mass spectrometry. Statistically significant false discovery rate (FDR)-adjusted p-values were observed for 18 glycans, eight that differed significantly… CONTINUE READING
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