The Serotonin Syndrome, Triptans, and the Potential for Drug–Drug Interactions

@article{Shapiro2007TheSS,
  title={The Serotonin Syndrome, Triptans, and the Potential for Drug–Drug Interactions},
  author={Robert E. Shapiro and Stewart J. Tepper},
  journal={Headache: The Journal of Head and Face Pain},
  year={2007},
  volume={47}
}
  • R. Shapiro, S. Tepper
  • Published 1 February 2007
  • Medicine
  • Headache: The Journal of Head and Face Pain
The serotonin syndrome is an acute adverse reaction to medications that enhance serotonergic activity. The severity of cases ranges from mild to fatal. Recently, the U.S. Food and Drug Administration issued an alert that the risk of developing serotonin syndrome may be increased by the concomitant administration of triptan medications with certain other medications. However, a review of published data does not allow an accurate assessment of such risks related to triptans. We conclude that it… 
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TLDR
Adverse events associated with migraine and medications are reviewed, and their implications in clinical treatment are reviewed.
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TLDR
The patient fulfilled the clinical features, but did not meet the Sterbach criteria because other aetiologies were not ruled out, and it is possible that additional definite cases may be reported with greater physician awareness of these potential drug interactions and serotonin syndrome.
Triptans and Serotonin Syndrome
  • R. Evans
  • Medicine
    Cephalalgia : an international journal of headache
  • 2008
TLDR
The patient fulfilled the clinical features, but did not meet the Sterbach criteria because other aetiologies were not ruled out, and it is possible that additional definite cases may be reported with greater physician awareness of these potential drug interactions and serotonin syndrome.
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