The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction.

@article{Goldstein2019TheSS,
  title={The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction.},
  author={Irwin Goldstein and Arthur L. Burnett and Raymond C. Rosen and Peter W Park and Vera J. Stecher},
  journal={Sexual medicine reviews},
  year={2019},
  volume={7 1},
  pages={
          115-128
        }
}
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56 Citations
Highly Influential Citations
2
Background Citations
18
Methods Citations
2

56 Citations

Citation Type

Citation Type

Assessment of a New Formulation of Sildenafil on Common Practice: An Observational Study
TLDR
Sildenafil-ODF seems beneficial for patients irrespective of the severity of the ED, and data suggest that the availability of the intermediate dose of 75 mg could add greater flexibility to the therapy.
Treatment of Poor Sperm Quality and Erectile Dysfunction With Oral Pentoxifylline: A Systematic Review
TLDR
PTX administration for the simultaneous treatment of poor sperm quality and mild ED in infertile men will highly enhance the treatment compliance, however, the finding should be treated carefully until validated by further studies.
Sildenafil beyond erectile dysfunction and pulmonary arterial hypertension: Thinking about new indications
TLDR
The results disclosed sildenafil can have beneficial effects in each organ such as heart, liver, kidney, brain, and intestines, and it has significantly improved the prognosis of organ ischemia in various animal models.
Minimally invasive therapies for Peyronie's disease: the current state of the art.
TLDR
Overall, a combination of oral, topical, injection and traction therapies may provide the most significant benefit among the non-surgical modalities for PD.
Visual Side Effects Linked to Sildenafil Consumption: An Update
TLDR
A literature review was performed using PubMed, Cochrane Library and Clinical Trials databases from 1990 up to 2020, focusing on the pathophysiology of visual disorders induced by sildenafil, to spot subpopulations with increased risk of developing undesirable visual side effects.
The Effect of Phosphodiesterase-type 5 Inhibitors on Erectile Function: An Overview of Systematic Reviews
TLDR
The existing evidence regarding the efficacy and safety of PDE5 inhibitors, compared to placebo, is low, and high-quality, head-to-head, trials comparing different Pde5 inhibitors are necessary to determine their ideal dosage and formulation based on their safety and efficacy profile.
Sildenafil‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: Case report with review
TLDR
A case of sildenafil induced hypersensitivity syndrome that is possibly the first one is reported and the medical literature on type of adverse cutaneous drug eruption due to sildanafil and other PDE5 inhibitors is reviewed.
The Sexual Long COVID (SLC): Erectile Dysfunction as a Biomarker of Systemic Complications for COVID-19 Long Haulers
Sildenafil: From angina to SARS-CoV-2
Sildenafil induced sexual aggression: coincidence, rarity, or under-reported side effect?
TLDR
This is the first report on sildenafil induced sexual aggression and an otherwise healthy 40-year-old man presented with a pathological increase in libido with sexual urges, and frequent episodes of domestic sexual violence.
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TLDR
Sildenafil is an effective oral treatment for ED that produces a penetrative erection as early as 12 min and for most patients, within 30 min after dosing, and a duration of action lasting at least 4 h.
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