The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth.

@article{Fernandez2006TheSP,
  title={The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth.},
  author={Pablo N Larrosa Fernandez and Brigitte Saint-Joanis and Nathalie Barilone and Mary Jackson and B. Gicquel and Stewart T Cole and Pedro M Alzari},
  journal={Journal of bacteriology},
  year={2006},
  volume={188 22},
  pages={7778-84}
}
The receptor-like protein kinase PknB from Mycobacterium tuberculosis is encoded by the distal gene in a highly conserved operon, present in all actinobacteria, that may control cell shape and cell division. Genes coding for a PknB-like protein kinase are also found in many more distantly related gram-positive bacteria. Here, we report that the pknB gene can be disrupted by allelic replacement in M. tuberculosis and the saprophyte Mycobacterium smegmatis only in the presence of a second… CONTINUE READING

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Two-component systems, protein kinases and signal transduction in Mycobacterium tuberculosis

  • Y. Av-Gay, V. Deretic
  • 2005
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