The Sequence of the Human Genome

@article{Venter2001TheSO,
  title={The Sequence of the Human Genome},
  author={J. Craig Venter and Mark D. Adams and Eugene W. Myers and Peter W. Li and Richard J. Mural and Granger G. Sutton and Hamilton O. Smith and Mark Yandell and Cheryl A. Evans and Robert A. Holt and Jeannine D. Gocayne and Peter G. Amanatides and Richard Ballew and Daniel H. Huson and Jennifer R. Wortman and Qing Zhang and Chinnappa D. Kodira and Xiangqun H. Zheng and Lin Chen and Marian Skupski and G. M. Subramanian and Paul D. Thomas and Jinghui Zhang and George L. Gabor Miklos and Catherine R. Nelson and Samuel E. Broder and Andrew G. Clark and Joe Nadeau and Victor A. McKusick and Norton D. Zinder and Arnold J. Levine and Richard J. Roberts and Melvin I. Simon and Carolyn W. Slayman and Michael W. Hunkapiller and Randall A. Bolanos and Arthur L. Delcher and Ian M. Dew and Daniel P. Fasulo and Michael Flanigan and Liliana D Florea and Aaron L. Halpern and Sridhar Hannenhalli and Saul A. Kravitz and Samuel Levy and Clark M. Mobarry and Knut Reinert and Karin A. Remington and Jane Abu-Threideh and Ellen M. Beasley and Kendra Biddick and Vivien Bonazzi and Rhonda Brandon and Michele Cargill and Ishwar Chandramouliswaran and Rosane Charlab and Kabir Chaturvedi and Zuoming Deng and Valentina Di Francesco and Patrick Dunn and Karen Eilbeck and Carlos Evangelista and Andrei E. Gabrielian and Weiniu Gan and Wangmao Ge and Fangcheng Gong and Zhiping Gu and Ping Guan and Thomas J. Heiman and Maureen E. Higgins and Rui-Ru Ji and Zhaoxi Ke and Karen A. Ketchum and Zhongwu Lai and Yiding Lei and Zhenya Li and Jiayin Li and Yong Liang and Xiaoying Lin and Fu Lu and Gennady V. Merkulov and Natalia Milshina and Helen M. Moore and Ashwinikumar K. Naik and Vaibhav A. Narayan and Beena A Neelam and Deborah R. Nusskern and Douglas B. Rusch and Steven L. Salzberg and Wei-zhi Shao and Bixiong Chris Shue and Jingtao Sun and Zhen Yuan Wang and Aihui Wang and Xiao-wen Wang and Jingwei Wang and M. H. Wei and Ron Wides and Chunlin Xiao and Chunhua Yan and Alison Yao and Jane Ye and M Zhan and Weiqing Zhang and Hongyu Zhang and Qi Zhao and Liansheng Zheng and Fei Zhong and Wenyan Zhong and Shiaoping C. Zhu and Shaying Zhao and Dennis A Gilbert and Suzanna Baumhueter and Gene Spier and Christine Carter and Anibal Cravchik and Trevor Woodage and Feroze Ali and Huijin An and Aderonke Awe and Danita Baldwin and H. Maria Baden and Mary Barnstead and Ian Barrow and Karen Beeson and Dana Busam and Amy L. Carver and Angela Center and Mingbo Cheng and Liz Curry and Steven Danaher and Lionel B. Davenport and Raymond Desilets and Susanne Malchau Dietz and K Dodson and Lisa Doup and Steve Ferriera and Neha Garg and Andres Gluecksmann and Britney Hart and Jason Haynes and Charles Haynes and Cheryl R. Heiner and Suzanne Lynn Hladun and Damon Hostin and Jarrett T. Houck and T. Howland and Chinyere Ibegwam and Jeffery E. Johnson and Francis Kalush and Lesley Kline and Shashi Koduru and Amy Love and Felecia Mann and David May and Steven McCawley and Tina C. McIntosh and I. McMullen and Mee C. Moy and Linda P Moy and Brian Murphy and Keith A. Nelson and Cynthia Pfannkoch and Eric C. Pratts and Vinita Puri and Hina-Ur-Razaq Qureshi and Matt Reardon and Robert Rodriguez and Y H Rogers and Deanna L. Romblad and Bob Ruhfel and Richard Scott and Cynthia D. Sitter and Michelle Smallwood and Erin Stewart and Renee Strong and Ellen Suh and Reginald William Thomas and Ni Ni Tint and Sukyee Tse and Claire Vech and Gary Wang and J. Gillis Wetter and Sherita M. Williams and Monica S. Williams and Sandra M. Windsor and E. Winn-Deen and Keriellen Wolfe and Jayshree Zaveri and K. Zaveri and Josep F. Abril and Roderic Guig{\'o} and Michael J. Campbell and Kimmen Sjolander and Brian Karlak and Anish Kejariwal and Huaiyu Mi and B. Lazareva and Thomas Hatton and Apurva Narechania and Karen Diemer and Anushya Muruganujan and Nan Guo and Shinji Sato and Vineet Bafna and Sorin Istrail and Ross Lippert and Russell Schwartz and Brian P. Walenz and Shibu Yooseph and David R. Allen and Anand Basu and J. W. Baxendale and L. W. Blick and Marcelo Caminha and John Carnes-Stine and Parris Caulk and Yen-Hui Chiang and My D. Coyne and Carl Dahlke and Anne Deslattes Mays and Maria Dombroski and Michael Donnelly and Dale Ely and Shiva Esparham and Carl Fosler and Harold Carey Gire and Stephen A. Glanowski and Kenneth W Glasser and Anna Głodek and Mark Gorokhov and Kennedy Terence Graham and Barry Gropman and Michael Harris and Jeremy Heil and Scott Henderson and Jeffrey Hoover and Donald Jennings and Catherine Jordan and James Jordan and John R. Kasha and Leonid Kagan and Cheryl L. Kraft and Alexander Levitsky and Mark G. Lewis and Xiangjun Liu and John Lopez and Daniel S. Ma and William H. Majoros and Joe R. McDaniel and Sean Murphy and M. Newman and Dac-Trung Nguyen and Ngoc Thuan Khanh Nguyen and Marc Nodell and Sue Pan and Jim Peck and Marshall Peterson and William H Rowe and Robert Sanders and John L. Scott and M. Simpson and Thomas J. Smith and A. Sprague and Timothy B. Stockwell and Russell J. Turner and Eli Venter and Mei Wang and Meiyuan Wen and David Wu and Mitchell M. Wu and Ashley Xia and Ali Zandieh and Xiaohong Zhu},
  journal={Science},
  year={2001},
  volume={291},
  pages={1304 - 1351}
}
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence reads (5.11-fold coverage of the genome) from both ends of plasmid clones made from the DNA of five individuals. Two assembly strategies—a whole-genome assembly and a regional chromosome assembly—were used, each combining sequence data from… Expand
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  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
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TLDR
Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Expand
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TLDR
A dynamic-programming based approach to sequence assembly validation and detection of large-scale polymorphisms within a population that is made possible through the availability of large human sequence contigs is discussed. Expand
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TLDR
A genome sequencing platform that achieves efficient imaging and low reagent consumption with combinatorial probe anchor ligation chemistry to independently assay each base from patterned nanoarrays of self-assembling DNA nanoballs is described. Expand
On the sequencing of the human genome
TLDR
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The results of the study suggest that the existing tools for computational determination of CpG islands fail to identify a significant fraction of functional CPG islands, and unmethylated DNA stretches with a high frequency of C pG dinucleotides can be found even in regions with low CG content. Expand
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