The Semiconserved Head Structure of Plasmodium falciparum Erythrocyte Membrane Protein 1 Mediates Binding to Multiple Independent Host Receptors

@article{Chen2000TheSH,
  title={The Semiconserved Head Structure of Plasmodium falciparum Erythrocyte Membrane Protein 1 Mediates Binding to Multiple Independent Host Receptors},
  author={Qijun Chen and Andreas Heddini and Antonio Barragan and V{\'i}ctor Fresno Fern{\'a}ndez and S. Frieda A. Pearce and Mats Wahlgren},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={1 - 10}
}
Erythrocytes infected with mature forms of Plasmodium falciparum do not circulate but are withdrawn from the peripheral circulation; they are bound to the endothelial lining and to uninfected erythrocytes in the microvasculature. Blockage of the blood flow, hampered oxygen delivery, and severe malaria may follow if binding is excessive. The NH(2)-terminal head structure (Duffy binding-like domain 1 [DBL1alpha]-cysteine-rich interdomain region [CIDR1alpha]) of a single species of P. falciparum… CONTINUE READING
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Erythrocyte glycans as Plasmodium falciparum rosetting receptors: molecular background of strain specific rosette disruption by glycosaminoglycans and sulfated glycoconjugates

  • A. Barragan, D. Spillmann, M. Wahlgren, J. Carlson
  • Exp. Parasitol
  • 1999
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