The Semen Microbiome and Its Relationship with Local Immunology and Viral Load in HIV Infection

@inproceedings{Liu2014TheSM,
  title={The Semen Microbiome and Its Relationship with Local Immunology and Viral Load in HIV Infection},
  author={Cindy Meng-Hsin Liu and Brendan J. W. Osborne and Bruce A Hungate and Kamnoosh Shahabi and Sanja Huibner and Richard A. Lester and Michael G. Dwan and Colin M. Kovacs and Tania L. Contente-Cuomo and Erika Benko and Maliha Aziz and Lance B Price and Rupert Kaul},
  booktitle={PLoS pathogens},
  year={2014}
}
Semen is a major vector for HIV transmission, but the semen HIV RNA viral load (VL) only correlates moderately with the blood VL. Viral shedding can be enhanced by genital infections and associated inflammation, but it can also occur in the absence of classical pathogens. Thus, we hypothesized that a dysregulated semen microbiome correlates with local HIV shedding. We analyzed semen samples from 49 men who have sex with men (MSM), including 22 HIV-uninfected and 27 HIV-infected men, at baseline… CONTINUE READING
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