The Selfish Segregation Distorter Gene Complex of Drosophila melanogaster

@article{Larracuente2012TheSS,
  title={The Selfish Segregation Distorter Gene Complex of Drosophila melanogaster},
  author={Amanda M. Larracuente and Daven C Presgraves},
  journal={Genetics},
  year={2012},
  volume={192},
  pages={33 - 53}
}
Segregation Distorter (SD) is an autosomal meiotic drive gene complex found worldwide in natural populations of Drosophila melanogaster. During spermatogenesis, SD induces dysfunction of SD+ spermatids so that SD/SD+ males sire almost exclusively SD-bearing progeny rather than the expected 1:1 Mendelian ratio. SD is thus evolutionarily “selfish,” enhancing its own transmission at the expense of its bearers. Here we review the molecular and evolutionary genetics of SD. Genetic analyses show that… 

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TLDR
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TLDR
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TLDR
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TLDR
This work investigates the evolution and genomic consequences of an autosomal multilocus, male meiotic drive system, Segregation Distorter (SD) in the fruit fly, Drosophila melanogaster, and reveals a recent chromosome-scale selective sweep mediated by strong epistatic selection for haplotypes carrying Sd, the main driving allele, and one or more factors within the double inversion.

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