The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses

@article{Turrigiano2008TheSN,
  title={The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses},
  author={Gina G. Turrigiano},
  journal={Cell},
  year={2008},
  volume={135},
  pages={422-435}
}
Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that neurons detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites. Additional mechanisms may allow local or network-wide changes in activity to be sensed… CONTINUE READING
Highly Influential
This paper has highly influenced 64 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 559 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 97 references

Differ - ential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor - alpha

  • D. Stellwagen, R. C. Malenka
  • J . Neurosci .
  • 2006
Highly Influential
7 Excerpts

The role of constraints in Hebbian learning

  • L. Minichiello, A. M. Calella, D. L. Medina, T. Bonhoeffer, R. Klein, M. Korte
  • Neural Comput .
  • 2002
Highly Influential
18 Excerpts

Similar Papers

Loading similar papers…