The Self‐Medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications

@article{Khantzian1997TheSH,
  title={The Self‐Medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications},
  author={E. Khantzian},
  journal={Harvard Review of Psychiatry},
  year={1997},
  volume={4},
  pages={231–244}
}
  • E. Khantzian
  • Published 1997
  • Psychology, Medicine
  • Harvard Review of Psychiatry
    • &NA; The self‐medication hypothesis of addictive disorders derives primarily from clinical observations of patients with substance use disorders. Individuals discover that the specific actions or effects of each class of drugs relieve or change a range of painful affect states. Self‐medication factors occur in a context of self‐regulation vulnerabilities–‐primarily difficulties in regulating affects, self‐esteem, relationships, and self‐care. Persons with substance use disorders suffer in the… CONTINUE READING
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    References

    SHOWING 1-10 OF 130 REFERENCES
    The Self-Medication Hypothesis of Addictive Disorders: Focus on Heroin and Cocaine Dependence
    • 1,663
    Drug abuse as self-medication for depression: an empirical study.
    • 216
    Blue mood, blackened lungs. Depression and smoking.
    • 103
    Subjective experiences related to alcohol use among schizophrenics.
    • 105
    Vulnerability to psychopathology in nicotine-dependent smokers: an epidemiologic study of young adults.
    • 130
    Adolescent drug use and psychological health. A longitudinal inquiry.
    • 1,265
    Alcohol dependence and anxiety disorders: what is the relationship?
    • 356
    • PDF
    Clinical effects of recent cocaine use on patients with acute schizophrenia.
    • 113
    A Hierarchical Model of Opiate Addiction: Failures of Self-Regulation as a Central Aspect of Substance Abuse
    • 13
    The prevalence of psychiatric disorders in patients with alcohol and other drug problems.
    • 710