The Secretion of Protein and of Some Electrolytes in Response to a- and β- Adrenergic Agonists by Rat Parotid and Submandibular Salivary Glands Enlarged by Chronic Treatment with Isoproterenol

@article{Abe1980TheSO,
  title={The Secretion of Protein and of Some Electrolytes in Response to a- and $\beta$- Adrenergic Agonists by Rat Parotid and Submandibular Salivary Glands Enlarged by Chronic Treatment with Isoproterenol},
  author={K. Abe and C. Dawes},
  journal={Journal of Dental Research},
  year={1980},
  volume={59},
  pages={1081 - 1089}
}
  • K. Abe, C. Dawes
  • Published 1980
  • Chemistry, Medicine
  • Journal of Dental Research
In comparison with control rats, chronic administration of isoproterenol (IPR) caused enlargement of the parotid and submandibular glands and the synthesis of apparently new proteins, probably by acinar cells. The parotid and submandibular saliva secreted in response to methoxamine or IPR differed markedly in protein and electrolyte content. In addition, with each stimulus, the salivas secreted by control and experimental glands differed in flow rate, protein concentration, and in the… Expand
The effects of oxymetazoline on secretion of protein and some electrolytes by rat submandibular and parotid glands.
  • K. Abe, C. Dawes
  • Chemistry, Medicine
  • Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
  • 1985
TLDR
Oxymetazoline is a potent secretagogue for the salivary glands of rats and activates preferentially alpha-adrenoceptors in the parotid gland and submandibular glands, which allows secretion of new types of proteins. Expand
The effects of alpha-methylnoradrenaline on protein and electrolyte secretion by rat submandibular and parotid glands.
  • K. Abe, C. Dawes
  • Chemistry, Medicine
  • Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
  • 1984
TLDR
Alpha-Methylnoradrenaline (alpha-mNA) is a potent secretagogue for the parotid and submandibular glands of rats and may not stimulate the specific alpha 2-adrenoceptors of the salivary glands of Rats. Expand
Dopamine-induced secretion of protein and of some electrolytes by rat submandibular and parotid glands.
TLDR
Parotid secretion was partially blocked by both phentolamine and haloperidol, suggesting that dopamine is also acting on α-adrenergic and on specific dopamine receptors, and the submandibular gland is able to secrete different types of proteins in response to α-ADrenergic agonists as opposed to β- adrenergic or cholinergic agonist. Expand
The storage and secretion of protein by the rat submandibular gland
TLDR
The proteins secreted by the rat submandibular gland in response to various secretory stimuli have been investigated and reserpine was found to cause an accumulation of carboxylated glycoproteins within the acini, which normally contain a neutral glycoprotein population. Expand
Changes in Protein Secretion by Rat Submandibular Glands in Response to Isoproterenol, a-Methylnoradrenaline, and Clonidine during Post-natal Development
TLDR
It is concluded that functional maturation precedes morphological maturation in the submandibular glands of rats in response to the β1-, α1-, and α2- adrenoceptor agonists, isoproterenol (IPR), a-methylnoradrenaline (a-mNA), and clonidine (Clonid). Expand
Effects of Parasympathomimetic and Sympathomimetic Drugs on the Secretion and Composition of Rat Sublingual Saliva
The sublingual glands of adult, male rats secreted considerable volumes of saliva in response to several cholinergic agonists, but very little in response to α-adrenergic stimuli and none in responseExpand
Amino acid composition of salivary protein secreted by the parotid glands of rats in response to parasympathomimetic and sympathomimetic drugs.
Although the total protein concentration in the saliva varied markedly, depending on the nature of the stimulus, the proportions of the amino-acid residues were independent on the nature of theExpand
Autonomic effects on protein secretion by rat submandibular salivary glands.
  • K. Abe
  • Biology, Medicine
  • Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
  • 1987
TLDR
1. Following treatment with cholinergic and beta-adrenergic drugs, the beta-type protein, associated with cAMP, was secreted regardless of the doses used and the alpha-typeprotein was completely converted to thebeta-type with alpha-blockers. Expand
Effects of the Selective β2-Adrenergic Agonists, Procaterole and Terbutaline, on Protein Secretion by Rat Submandibular Glands
We examined the secretory effects of two β2-adrenergic agonists, procaterole and terbutaline, on the submandibular glands of anesthetized rats. After stimulation with these agents with and without aExpand
The Effects of Tyramine on Salivary Flow Rate and Protein Secretion by Rat Submandibular Glands
TLDR
P-tyramine may activate both the α1- and β1adrenoceptors in the submandibular glands of rats directly or indirectly and be significantly reduced with all autonomic blockers except the lowest doses of β-blockers, atropine, and yohimbine. Expand
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References

SHOWING 1-10 OF 32 REFERENCES
The effects of electrical and pharmacological stimulation on the types of proteins secreted by rat parotid and submandibular glands.
TLDR
No differences in the types or proportions of the different proteins were detected in saliva elicited by electrical stimulation of the parasympathetic nerve to the glands, by cholinergic or by α- or β-adrenergic agonists, despite large differences in salivary flow rates and protein concentrations in response to those different stimuli. Expand
Effect of Isoproterenol on Calcium Metabolism in Rat Salivary Gland.∗
  • R. Dreisbach
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1964
TLDR
Repeated twice daily subcutaneous administration of isoproterenol increases the weight of submaxillary and parotid glands by up to 6-fold and the Ca content of sub maxillary gland to double the initial concentration. Expand
Role of β-Receptors in Sympathetic Regulation of Electrolytes in Rat Submaxillary Saliva.∗
Summary Electrolyte composition ([K], [Na], [Cl], [HCO3]) and flow rate have been characterized in rat submaxillary saliva evoked by electrical stimulation of the sympathetic innervation. [K] andExpand
Isoproterenol-induced stimulation of sodium absorption in perfused salivary duct.
TLDR
Administration of isoproterenol, as a single intraperitoneal dose of approximately 13 pg/kg body wt produced a sustained elevation in net efflux of Na from the lumen of the submaxillary main excretory duct during perfusion with isotonic NaCl solutions. Expand
Changes in Rat Parotid Salivary Proteins Induced by Chronic Isoproterenol Administration
TLDR
Changes in the rat parotid gland and its secretion, brought about by chronic isoproterenol administration, and morphological and biochemical analyses showed evidence of changes in the secretory components. Expand
Circadian variations in pilocarpine and isoprenaline-induced protein secretion by rat parotid gland.
TLDR
It is suggested that with only a moderate stimulus the amount of protein secreted is independent of the amount in the gland, at least within the limits of the normal circadian variation in gland content of secretory protein. Expand
The effects of flow rate and duration of stimulation on the concentrations of protein and the main electrolytes in human submandibular saliva.
  • C. Dawes
  • Chemistry, Medicine
  • Archives of oral biology
  • 1974
TLDR
With stimulation, the pH, ionic strength and the concentrations of protein, sodium, calcium, chloride and bicarbonate increased in proportion to flow rate, the potassium concentration remained almost constant whilst the magnesium and phosphate concentrations decreased, the former being independent of stimulated flow rate but the latter being inversely related to flow rates. Expand
Fine structure of the differentiating acini in submandibular glands of isoproterenol-treated rats.
TLDR
It is concluded that precocious differentiation of the submandibular gland may be induced by the administration of isoproterenol as early as the first day of postnatal life, that proacinar cells become recognized as acinar cells following a change in the nature of their secretory product. Expand
Neural Regulation of Calcium and Amylase of Rat Parotid Saliva 1
TLDR
The course of amylase and calcium secretion into saliva is described under diverse conditions of autonomic stimulation of parotid and it is suggested that with cholinergic nerve stimulation mediation of calcium andAmylase secretion may differ from that observed with adrenergic stimulation. Expand
The Effect of Isoproterenol-induced Salivary-Gland Hypertrophy and Diet on the Chemistry of Rat Saliva
The relationship between oral health and saliva chemistry has been extensively investigated.' Weber,2 among others, has proposed that there may be some correlations between chemical constituents ofExpand
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