The Second Window of Preconditioning (SWOP) Where Are We Now?

  title={The Second Window of Preconditioning (SWOP) Where Are We Now?},
  author={Derek Hausenloy and Derek M Yellon},
  journal={Cardiovascular Drugs and Therapy},
A standard ischemic preconditioning (IPC) stimulus of one or more brief episodes of non-lethal myocardial ischemia and reperfusion elicits a bi-phasic pattern of cardioprotection. The first phase manifests almost immediately following the IPC stimulus and lasts for 1–2 h, after which its effect disappears (termed classical or early IPC). The second phase of cardioprotection appears 12–24 h later and lasts for 48–72 h (termed the Second Window of Protection [SWOP] or delayed or late IPC). The… CONTINUE READING