The Second Gaddum Lecture: its origins and outcomes

  title={The Second Gaddum Lecture: its origins and outcomes},
  author={Y. Bakhle},
  journal={British Journal of Pharmacology},
  pages={969 - 977}
  • Y. Bakhle
  • Published 2019
  • Medicine
  • British Journal of Pharmacology
Fifty years ago, the BJP published the Second Gaddum Lecture, given by John Vane to the British Pharmacological Society. This article assesses the origins of the experiments described in the Lecture, linking them directly to Gaddum's use of bioassay, a defining feature of pharmacology. The outcomes of those experiments are also assessed, tracking those results that have survived the past five decades. Two of the major advances in cardiovascular medicine, the ACE inhibitors, as anti… Expand


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