The Sea Lamprey as an Etiological Model for Biliary Atresia

  title={The Sea Lamprey as an Etiological Model for Biliary Atresia},
  author={Yu-Wen Chung-Davidson and Chu‐Yin Yeh and W. Li},
  journal={BioMed Research International},
  • Yu-Wen Chung-Davidson, Chu‐Yin Yeh, W. Li
  • Published 2015
  • Biology, Medicine
  • BioMed Research International
  • Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes developmental BA with transient cholestasis and fibrosis during metamorphosis, but emerges as a fecund adult with steatohepatitis and fibrosis in the liver. In this paper, we present new histological evidence and… CONTINUE READING
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