The Schizosaccharomyces pombe rad3 checkpoint gene.

  title={The Schizosaccharomyces pombe rad3 checkpoint gene.},
  author={Nicola J. Bentley and Douglas A. Holtzman and Gail Flaggs and Kathleen S. Keegan and Anthony J Demaggio and Justin C Ford and Merl F. Hoekstra and Antony M Carr},
  journal={The EMBO journal},
  volume={15 23},
The rad3 gene of Schizosaccharomyces pombe is required for checkpoint pathways that respond to DNA damage and replication blocks. We report the complete rad3 gene sequence and show that rad3 is the homologue of Saccharomyces cerevisiae ESR1 (MEC1/SAD3) and Drosophila melanogaster mei-41 checkpoint genes. This establishes Rad3/Mec1 as the only conserved protein which is required for all the DNA structure checkpoints in both yeast model systems. Rad3 is an inessential member of the 'lipid kinase… CONTINUE READING
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