The Schizosaccharomyces pombe pla1 gene encodes a poly(A) polymerase and can functionally replace its Saccharomyces cerevisiae homologue

@article{Ohnacker1996TheSP,
  title={The Schizosaccharomyces pombe pla1 gene encodes a poly(A) polymerase and can functionally replace its Saccharomyces cerevisiae homologue},
  author={Martin Ohnacker and Lionel Minvielle-Sebastia and Walter Keller},
  journal={Nucleic acids research},
  year={1996},
  volume={24 13},
  pages={2585-91}
}
We have isolated the poly(A) polymerase (PAP) encoding gene pla1 [for poly(A) polymerase] from the fission yeast Schizosaccharomyces pombe. Protein sequence alignments with other poly(A) polymerases reveal that pla1 is more closely related to Saccharomyces cerevisiae PAP than to bovine PAP. The two yeast poly(A) polymerases share significant sequence homology not only in the generally conserved N-terminal part but also in the C-terminus. Furthermore, pla1 rescues a S. cerevisiae PAP1 disruption… CONTINUE READING
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Diploma Thesis, University of Basel

  • P. J. Preker, J. Lingner, L. Minvielle-Sebastia, W. Keller
  • 1992

Doctoral Thesis, University of Basel

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