The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication.

@article{Yoshida2003TheSP,
  title={The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication.},
  author={Shu-hei Yoshida and Hiba Al-Amodi and Taro Nakamura and Christopher J. McInerny and Chikashi Shimoda},
  journal={Genetics},
  year={2003},
  volume={164 3},
  pages={881-93}
}
We have defined five sev genes by genetic analysis of Schizosaccharomyces pombe mutants, which are defective in both proliferation and sporulation. sev1(+)/cdt2(+) was transcribed during the G1-S phase of the mitotic cell cycle, as well as during the premeiotic S phase. The mitotic expression of cdt2(+) was regulated by the MCB-DSC1 system. A mutant of a… CONTINUE READING