The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the periodic expression of histone genes and contributes to the function of complex centromeres.

@article{Blackwell2004TheSP,
  title={The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the periodic expression of histone genes and contributes to the function of complex centromeres.},
  author={Chris Blackwell and Kate A Martin and Amanda Greenall and Alison L. Pidoux and Robin C. Allshire and Simon K. Whitehall},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 10},
  pages={4309-20}
}
HIRA-like (Hir) proteins are evolutionarily conserved and are implicated in the assembly of repressive chromatin. In Saccharomyces cerevisiae, Hir proteins contribute to the function of centromeres. However, S. cerevisiae has point centromeres that are structurally different from the complex centromeres of metazoans. In contrast, Schizosaccharomyces pombe has complex centromeres whose domain structure is conserved with that of human centromeres. Therefore, we examined the functions of the… CONTINUE READING

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