The Schizophrenia-Associated Kv11.1-3.1 Isoform Results in Reduced Current Accumulation during Repetitive Brief Depolarizations

@inproceedings{Heide2012TheSK,
  title={The Schizophrenia-Associated Kv11.1-3.1 Isoform Results in Reduced Current Accumulation during Repetitive Brief Depolarizations},
  author={Juliane Heide and Stefan A. Mann and Jamie I. Vandenberg},
  booktitle={PloS one},
  year={2012}
}
Recent genome wide association studies identified a brain and primate specific isoform of a voltage-gated potassium channel, referred to as Kv11.1-3.1, which is significantly associated with schizophrenia. The 3.1 isoform replaces the first 102 amino acids of the most abundant isoform (referred to as Kv11.1-1A) with six unique amino acids. Here we show that the Kv11.1-3.1 isoform has faster rates of channel deactivation but a slowing of the rates of inactivation compared to the Kv11.1-1A… CONTINUE READING

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References

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Showing 1-10 of 24 references

A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia

SJ Huffaker, J Chen, KK Nicodemus, F Sambataro, F Yang
Nat Med • 2009
View 8 Excerpts
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The KCNH2 gene is associated with neurocognition and the risk of schizophrenia.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry • 2013
View 1 Excerpt

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